A new approach to the analysis of intact MUPs (Major Urinary Proteins) from mice by CESI-MS
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چکیده
The Major Urinary Proteins (MUPs) of the house mouse, Mus musculus domesticus, are 19 kDa beta-barrel lipocalins that are involved in chemical communication between individuals. Many of them are excreted in urine where they play multiple roles, including coding of owner identity and transport, and slow release of bound volatile pheromones. It has been shown that mass spectrometric analysis of intact proteins, is capable of dissecting subtle structural differences between the members of this class of proteins. Moreover, mass spectrometric analysis of the intact proteins can contribute towards molecular phenotyping of MUPs .
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متن کاملRegulation of highly homologous major urinary proteins in house mice quantified with label-free proteomic methods† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6mb00278a Click here for additional data file.
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تاریخ انتشار 2017